- Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.
Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.
Journal of natural products (2005-11-29)
Flor Soriano-Agatón, Delphine Lagoutte, Erwan Poupon, François Roblot, Alain Fournet, Jean-Charles Gantier, Reynald Hocquemiller
PMID16309303
ABSTRACT
Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.
MATERIALS