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Key Documents

E9645

Sigma-Aldrich

Estrone sulfamate

≥98%

Synonym(s):

1,3,5(10)-Estratrien-17-one 3-sulfamate

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About This Item

Empirical Formula (Hill Notation):
C18H23NO4S
CAS Number:
148672-09-7
Molecular Weight:
349.44
MDL number:
MFCD00676965
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

Assay

≥98%

form

powder

storage temp.

−20°C

InChI

1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1

InChI key

RVKFQAJIXCZXQY-CBZIJGRNSA-N

Application

Lead compound for design of steroid sulfatase inhibitors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Purohit et al.
Biochemistry, 34(36), 11508-11514 (1995-09-12)
Steroid sulfatases are responsible for the hydrolysis of 3beta-hydroxy steroid sulfates, such as cholesterol and pregnenolone sulfate, and have an important role in regulating the synthesis of estrogenic steroids, from estrone sulfate and dehydroepiandrosterone sulfate, in endocrine-dependent tumors. Although little
Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.
L W Woo et al.
Journal of medicinal chemistry, 39(7), 1349-1351 (1996-03-29)

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