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Key Documents

B9806

Sigma-Aldrich

Heparin−biotin sodium salt

≥97%

Synonym(s):

Heparin-Biotin Conjugate

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10 MG
€304.00

€304.00

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10 MG
€304.00

About This Item

MDL number:
MFCD03457057
UNSPSC Code:
12352201
eCl@ss:
34058011
NACRES:
NA.25

€304.00

Please contact Customer Service for Availability
Request a Bulk Order

conjugate

biotin conjugate

Quality Level

200

Assay

≥97%

form

solid

mol wt

~15000 Da

solubility

H2O: soluble 1 mg/mL, clear, colorless

storage temp.

2-8°C

Application

Heparin-biotin is used transfection research for the development of self-assembled terplexes such as polyamidoamine dendrimer and DNA (PAMAM/DNA) heparin-biotin terplexes for targeted gene delivery with improved transfection. The terplexes may be used in immobilizing proteins such as lactoferrin and lysozyme and nucleic acids.[1][2]

Other Notes

Biotin conjugated to heparin from porcine intestinal mucosa

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT6676
MKCS7114
MKCQ8048
MKCP6851
MKCN8218

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S Zou et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 889-895 (1992-12-01)
1. Binding of biotin-heparin to immobilized lactoferrin and lysozyme was optimum at pH 6.0, 100 mM NaCl. Complex interactions between NaCl and CaCl2 concentrations were observed for heparin binding to both proteins. 2. The metal ions Cu2+, Zn2+, Fe2+ and
Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
Dzmitry Shcharbin et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 110-127 (2009-10-10)
This paper reviews different techniques for analyzing the transfection efficiencies and cytotoxicities of dendriplexes-complexes of nucleic acids with dendrimers. Analysis shows that three plasmids are mainly used in transfection experiments: plasmid DNA encoding luciferase from the firefly Photinus pyralis, beta-galactosidase
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Questions

  1. Hello, is this product (B9806) a mixture of heparin lengths? How accurate is your estimation that it is 15000 daltons in size? How is this product made? Synthetically or by purification from an animal sample?

    1 answer

    1. The quality specification for product B9806 is that the molecular weight is approximately 15000 Daltons. This is only an approximation and no specific screening has been performed for other chain lengths. The source of the heparin is from porcine intestinal mucosa. The biotinylation method is considered proprietary.

      The following reference provides information on the biotinylation of heparin:
      Stearns, N., et al., Synthesis and Characterization of Highly Sensitive Heparin Probes for Detection of Heparin-Binding Proteins. Analytical Biochemistry, 247, 348 (1997).

      Helpful?

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