PTTG1
pituitary tumor-transforming 1
Synonyms:
EAP1, HPTTG, PTTG, TUTR1
Species:
Human PTTG1 (9232), Mouse Pttg1 (30939), Rat Pttg1 (64193), Zebrafish pttg1 (100307086), domestic guinea pig Pttg1 (100717950), sheep PTTG1 (101116829), cow PTTG1 (508043), domestic cat PTTG1 (101084421), dog PTTG1 (479307), chicken PTTG1 (416158)
UniProtKB ID:
Gene ID:
- Human(9232) Summary: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008]
- Mouse(30939) pituitary tumor-transforming gene 1
- Rat(64193) pituitary tumor-transforming 1
- Zebrafish(100307086) pituitary tumor-transforming 1
- domestic guinea pig(100717950) pituitary tumor-transforming 1
- sheep(101116829) pituitary tumor-transforming 1
- cow(508043) pituitary tumor-transforming 1
- domestic cat(101084421) pituitary tumor-transforming 1
- dog(479307) pituitary tumor-transforming 1
- chicken(416158) pituitary tumor-transforming 1
- naked mole-rat(101723041) pituitary tumor-transforming 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PTTG1 antibody produced in mouse, clone 1D9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-PTTG1 antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunofluorescence
Anti-PTTG1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-PTTG1 antibody produced in mouse, clone 3H8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-PTTG1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot