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Merck

MYLK

myosin light chain kinase

Synonyms:
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
Species:
UniProtKB ID:
Gene ID:
  • Human(4638) Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
  • Mouse(107589) myosin, light polypeptide kinase
  • Rat(288057) myosin light chain kinase
  • domestic guinea pig(100714177) myosin light chain kinase
  • dog(488012) myosin light chain kinase
  • naked mole-rat(101704236) myosin light chain kinase
  • chicken(396445) myosin light chain kinase
  • Domestic Rabbit(100009143) myosin light chain kinase
  • sheep(443334) myosin light chain kinase
  • cow(338037) myosin light chain kinase
  • Horse(100070482) myosin light chain kinase

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-MLCK(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Anti-MYLK antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse, clone K36, ascites fluid,
Species Reactivity
avian, mammals
Application
immunoprecipitation (IP)
microarray

western blot
Monoclonal Anti-MYLK antibody produced in mouse, clone 1D1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-MYLK antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
proximity ligation assay
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
ML-7, powder,
Species
human

Proteins

Product Number
Description
Species
MLCK (1425-1776), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
MLCK Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, human MLCK, amino acids 1425-1771, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MYLK (2),
Species
human
MISSION® esiRNA, targeting mouse Mylk,
Species
mouse
MISSION® esiRNA, targeting human MYLK (1),
Species
human