DCX
doublecortin
Synonyms:
DBCN, DC, LISX, SCLH, XLIS
Species:
Human DCX (1641), Mouse Dcx (13193), Rat Dcx (84394), chicken DCX (374242), dog DCX (612950), domestic cat DCX (494212), cow DCX (787968), Horse DCX (100058909), sheep DCX (101109861), naked mole-rat Dcx (101711611)
UniProtKB ID:
Gene ID:
- Human(1641) Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
- Mouse(13193) doublecortin
- Rat(84394) doublecortin
- chicken(374242) doublecortin
- dog(612950) doublecortin
- domestic cat(494212) doublecortin
- cow(787968) doublecortin
- Horse(100058909) doublecortin
- sheep(101109861) doublecortin
- naked mole-rat(101711611) doublecortin
- domestic guinea pig(100713827) doublecortin
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Doublecortin antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-DCX antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-DCX (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-DCX (AB2) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, horse, human, mouse, pig
Application
western blot
Anti-Doublecortin Antibody, clone 6H1B3, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
western blot
esiRNA
Product Number
Description
Species