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Merck

CACNA1F

calcium channel, voltage-dependent, L type, alpha 1F subunit

Synonyms:
AIED, COD3, COD4, CORDX, CORDX3, CSNB2, CSNB2A, CSNBX2, Cav1.4, Cav1.4alpha1, JM8, JMC8, OA2
Species:
UniProtKB ID:
Gene ID:
  • Human(778) Summary: This gene encodes a member of the alpha-1 subunit family; a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been shown to cause incomplete X-linked congential stationary night blindness type 2 (CSNB2). [provided by RefSeq, Feb 2012]
  • Mouse(54652) calcium channel, voltage-dependent, alpha 1F subunit
  • Rat(114493) calcium channel, voltage-dependent, L type, alpha 1F subunit
  • sheep(101104552) calcium channel, voltage-dependent, L type, alpha 1F subunit
  • naked mole-rat(101722090) calcium channel, voltage-dependent, L type, alpha 1F subunit
  • domestic guinea pig(100720484) calcium channel, voltage-dependent, L type, alpha 1F subunit
  • Zebrafish(386662) calcium channel, voltage-dependent, alpha 1F subunit
  • domestic cat(101080870) calcium channel, voltage-dependent, L type, alpha 1F subunit
  • dog(480915) calcium channel, voltage-dependent, L type, alpha 1F subunit
  • cow(509779) calcium channel, voltage-dependent, L type, alpha 1F subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CACNA1F antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Blocker

Product Number
Description
Species
Isradipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Nicardipine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Nifedipine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Nicardipine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Amlodipine besylate, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA1F,
Species
human