BBC3
BCL2 binding component 3
Synonyms:
JFY-1, JFY1, PUMA
Species:
Human BBC3 (27113), Mouse Bbc3 (170770), Rat Bbc3 (317673), dog BBC3 (612153), Zebrafish bbc3 (751763), domestic guinea pig Bbc3 (101788977), naked mole-rat Bbc3 (101714844), cow BBC3 (782359)
UniProtKB ID:
Gene ID:
- Human(27113) Summary: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
- Mouse(170770) BCL2 binding component 3
- Rat(317673) Bcl-2 binding component 3
- dog(612153) BCL2 binding component 3
- Zebrafish(751763) BCL2 binding component 3
- domestic guinea pig(101788977) BCL2 binding component 3
- naked mole-rat(101714844) BCL2 binding component 3
- cow(782359) BCL2 binding component 3
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PUMA (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-PUMA antibody produced in mouse, clone 10C5G1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, rat
Application
ELISA
western blot
western blot
Monoclonal Anti-PUMA antibody produced in mouse, clone 2A9G5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
western blot