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SML3856

Sigma-Aldrich

Alisporivir

≥95% (HPLC)

Synonym(s):

Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl-(2S)-2-aminobutanoyl-N-methyl-D-alanyl-N-ethyl-L-valyl-L-valyl-N-methyl-L-leucyl], DEB025, Debio 025

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About This Item

Empirical Formula (Hill Notation):
C63H113N11O12
CAS Number:
254435-95-5
Molecular Weight:
1216.64
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

color

white to off-white

storage temp.

-10 to -25°C

Biochem/physiol Actions

Alisporivir is a Cyclophilin A inhibitor with potent anti-hepatitis C virus (HCV) activity. Alisporivir has also been investigated for Duchenne muscular dystrophy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
PLoS ONE, 5(10) (2010)
Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs
ACS infectious diseases, 4(2), 88-92 (2018)
Alisporivir rescues defective mitochondrial respiration in Duchenne muscular dystrophy
Pharmacological Research, 125(Pt B), 122-131 (2017)

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