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328103

Sigma-Aldrich

3′-Hydroxyacetophenone

≥99%

Synonym(s):

1-(3-Hydroxyphenyl)ethanone, 3-Acetylphenol, 3-Hydroxyphenylethanone, m-Hydroxyacetophenone

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About This Item

Linear Formula:
HOC6H4COCH3
CAS Number:
121-71-1
Molecular Weight:
136.15
Beilstein:
2040676
EC Number:
204-494-0
MDL number:
MFCD00002298
UNSPSC Code:
12352100
PubChem Substance ID:
24859714
NACRES:
NA.22

Assay

≥99%

bp

296 °C (lit.)

mp

90-95 °C (lit.)

density

1.1 g/mL at 25 °C (lit.)

SMILES string

CC(=O)c1cccc(O)c1

InChI

1S/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3

InChI key

LUJMEECXHPYQOF-UHFFFAOYSA-N

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General description

3′-Hydroxyacetophenone is an hydroxy-substituted alkyl phenyl ketone.

Application

3′-Hydroxyacetophenone was used in synthesis of enantiopure (-)-rivastigmine. It was also used in preparation of building block for synthesis of dendritic compounds.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

247.3 °F - closed cup

Flash Point(C)

119.6 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis of polyester dendrimers and dendrons starting from Michael reaction of acrylates with 3-hydroxyacetophenone.
Hirayama Y, et a
Tetrahedron Letters, 46(6), 1027-1030 (2005)
Kiwon Han et al.
The Journal of organic chemistry, 75(9), 3105-3108 (2010-03-30)
A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone
Katharine Moore Tibbetts et al.
The journal of physical chemistry. A, 118(37), 8170-8176 (2014-03-01)
The hydroxy-substituted alkyl phenyl ketones 2'-, 3'- and 4'- (ortho, meta, and para) hydroxyacetophenone were excited in the strong-field regime with wavelengths ranging from 1200-1500 nm to produce the respective radical cations. For 2'- and 3'-hydroxyacetophenone, the parent molecular ion
Takashi Otani et al.
Bioorganic & medicinal chemistry letters, 18(12), 3582-3584 (2008-05-31)
m-Acetylphenyl-beta-d-glucopyranosides and m-acetylphenyl-alpha/beta-d-mannopyranosides were synthesized by the Koenigs-Knorr, Mitsunobu, and Helferich reactions as key glycosylation reactions, respectively. Their spectroscopic properties and antioxidative activities were characterized as potential ultraviolet B-ray absorbents.
Stefania Ferrari et al.
Journal of medicinal chemistry, 54(1), 211-221 (2010-12-04)
Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify new molecules with specificity for PTR1, we carried out a virtual screening of the Available Chemicals
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