Residual solvents in pharmaceutical preparations

SPME fiber

polydimethylsiloxane, 100 μm (57300-U)

extraction

headspace or immersion sampling (15 min) 1 min desorption

column

SPB-624, 75 m × 0.53 mm I.D., 3.0 μm (25432)

oven

40 °C (35 min) to 220 °C at 40 °C/min, hold 5 min

inj. temp.

splitless (closed 3 min), 200 °C

detector

FID, 250 °C

carrier gas

helium, 35 cm/sec