The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.

Nature communications (2016-11-25)

Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann

PMID27882935

RESUMEN

Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4

MATERIALES

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Marca

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F8630

Sigma-Aldrich

Fibrinógeno from bovine plasma, Type I-S, 65-85% protein (≥75% of protein is clottable)

H3149

Sigma-Aldrich

Heparina sodium salt from porcine intestinal mucosa, Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture

EHU076591

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO1

EHU146321

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO4

EHU058661

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MISSION^® esiRNA, targeting human ROBO2

EHU124361

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MISSION^® esiRNA, targeting human UNC5B