- Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.
Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.
Il Farmaco; edizione scientifica (1984-01-01)
S Banfi, W Fonio, E Allievi, M Pinza, L Dorigotti
PMID6538512
RESUMEN
A number of N-substituted 4-hydroxy-, 4-acyloxy- and 4-alkoxy-2-pyrrolidinones were examined by a screening method predictive of their activity on cognitive processes. The 1-aminocarbonylmethyl-substituted compounds showed a favorable effect on learning and memory, and among them the most active was the 4-hydroxy derivative, oxiracetam, which had a potency considerably higher than piracetam, used for comparison purposes.