- Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
Bioorganic & medicinal chemistry letters (1999-11-24)
S De Jonghe, I Van Overmeire, J Gunst, A De Bruyn, C Hendrix, S Van Calenbergh, R Busson, D De Keukeleire, J Philippé, P Herdewijn
PMID10560744
RESUMEN
Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.
MATERIALES
Referencia del producto
Marca
Descripción del producto