SRP6057
Activin A from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinónimos:
FRP, FSH-releasing protein, Inhibin beta-1
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
mouse
recombinante
expressed in E. coli
Análisis
≥95% (HPLC)
≥95% (SDS-PAGE)
formulario
lyophilized
mol peso
26.2 kDa
envase
pkg of 10 μg
técnicas
cell culture | embryo: suitable
Nº de acceso NCBI
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... INHBA(3624)
Descripción general
Activin A is a member of the TGF (transforming growth factor)-β family of proteins produced by many cell types throughout development. Mouse Activin A has 100% amino acid sequence identity to human, rat, porcine, bovine and feline proteins. Recombinant mouse Activin A is a nonglycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa.
Aplicación
Activin A has been used:
- to induce differentiation of embryonic stem cells to pancreatic β cells
- in the induction of bone marrow-derived mesenchymal stem cells to insulin-producing cells
- to induce endoderm differentiation from human embryonic stem cells
- as a component of β cell induction medium.
Acciones bioquímicas o fisiológicas
Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two β A chains and is not biologically active until the N terminal propeptide is cleaved from each chain. Activin A is involved in mesoderm formation and hematopoietic development.
Forma física
Recombinant mouse Activin A is lyophilized with 0.02% TFA.
Nota de preparación
Centrifuge the vial prior to opening.
Reconstitución
Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
Otras notas
MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Skin Irrit. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
In vitro derivation of functional insulin-producing cells from human embryonic stem cells.
Jiang W
Cell Research, 17, 333-344 (2007)
Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid.
Shi Y
Stem Cells, 23, 656-662 (2005)
Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.
Gray AM
Science, 247, 1328-1330 (1990)
Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro.
Sun Y
Chinese Medical Journal (English Edition), 120, 771-776 (2007)
Different phenotypes for mice deficient in either activins or activin receptor type II.
Matzuk MM
Nature, 374, 356-360 (1995)
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