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SRP4869

Sigma-Aldrich

Placental Lactogen human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinónimos:

CSA, CSH1, CSH2, CSMT, FLJ75407, PL

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About This Item

Número MDL:
Código UNSPSC:
51111800
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

Análisis

≥95% (HPLC)
≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

~22.3 kDa

envase

pkg of 20 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell based assay: suitable

impurezas

endotoxin, tested

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... CSH1(1442)

Descripción general

Human placental lactogen (HPL), also called human chorionic somatomammotropin 1, is a polypeptide placental hormone. Its structure and function is similar to that of growth hormone. The gene encoding this protein is localized on human chromosome 17. Recombinant human placental lactogen is a 22.3kDa protein.

Acciones bioquímicas o fisiológicas

Human placental lactogen (HPL) modifies the metabolic state of the mother during pregnancy to facilitate the energy supply, glucose supply and growth of the fetus. Studies show that targeted expression of this protein in transgenic mice lead to an increase in proliferation of β-cells.

Forma física

Sterile filtered and lyophilized with no additives.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Zinuo Chen et al.
Cell & bioscience, 11(1), 45-45 (2021-03-01)
In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Freathy RM
Journal of Negative Results in Biomedicine, 5, 18-18 (2006)
Meltem Muftuoglu et al.
Nucleic acids research, 34(1), 295-304 (2006-01-18)
Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, severe neurological abnormalities and prageroid symptoms. The CS complementation group B (CSB) protein is involved in UV-induced transcription coupled repair (TCR), base excision repair and general
Placental lactogen is expressed but is not translated into protein in breast cancer.
Tuttle TR
PLoS ONE, 9(1), e87325-e87325 (2014)
Jaeyong Cho et al.
Biochemical and biophysical research communications, 579, 110-115 (2021-10-02)
The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones

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