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Merck
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SRP4363

Sigma-Aldrich

VEGF165 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sinónimos:

Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VPF, Vascular Endothelial Growth Factor

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About This Item

Número MDL:
MFCD00286542
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

Análisis

≥98% (HPLC)
≥98% (SDS-PAGE)

formulario

lyophilized

potencia

1.0-7.0 ng/mL

mol peso

~38.2 kDa

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

impurezas

endotoxin, tested

Nº de acceso NCBI

Q96KJ0

Nº de acceso UniProt

P15692

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... VEGFA(7422)

Descripción general

The gene VEGFA (vascular endothelial growth factor A) is a member of VEGF family of growth factors. The gene is localized to human chromosome 6p21.1. It contains eight exons interspaced by seven introns, spanning a length of 14 kb. The critical region of 2.36 kbp in human promoter lacks a consensus TATA box. However, it contains various consensus-binding sites for many transcriptional regulators.

Acciones bioquímicas o fisiológicas

The gene VEGFA (vascular endothelial growth factor A) encodes a secreted mitogen that is found to participate in physiological and pathological angiogenesis. It serves as a growth factor for endothelial cells and functions in the formation of new blood vessels during embryonic development and adulthood. It binds to two tyrosine kinase receptors VEGFR1 and VEGFR2 and functions in angiogenesis and maintenance of vasculature.

Forma física

Lyophilized with no additives.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese.
Lu F
Journal of Human Genetics, 57, 320-325 (2012)
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.
Lee S
The Journal of Cell Biology, 169, 681-691 (2005)
Vivian Lehmann et al.
Biotechnology progress, 35(2), e2745-e2745 (2018-11-14)
The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to
VEGFA is necessary for chondrocyte survival during bone development.
Zelzer E
Development, 131, 2161-2171 (2004)
Vivian Lehmann et al.
Biotechnology progress, 35(2), e2745-e2745 (2018-11-14)
The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to

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