SAE0005
Glucose-6-phosphate Isomerase human
recombinant, expressed in E. coli
Sinónimos:
GPI, PGI
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About This Item
Productos recomendados
recombinante
expressed in E. coli
Nivel de calidad
Análisis
≥95% (SDS-PAGE)
actividad específica
≥200 units/mg protein
temp. de almacenamiento
−20°C
Acciones bioquímicas o fisiológicas
Glucose-6-phosphate isomerase (GPI) is a homodimeric enzyme ubiquitously present in most organisms. GPI catalyzes the interconversion between glucose-6-phosphate and fructose-6-hosphate, the second step of the glycolytic pathway. In mammals, Glucose-6-phosphate isomerase also acts as an autocrine motility factor (AMF), a neuroleukin, and a maturation factor. GPI deficiency is the second most common erythroenzymopathy of glycolytic enzymes after pyruvate kinase deficiency. Inherited deficiency of the enzymatic activity of GPI causes hereditary nonspherocytic hemolytic anemia (HNSHA) in humans, a severe deficiency that can be associated with hydrops fetalis (a-thalassaemia), immediate neonatal death, and neurological impairment.
Propiedades físicas
C-terminal histidine-tagged
Definición de unidad
One unit will convert 1.0 mmole of D-fructose 6-phosphate to D-glucose 6-phosphate per inute at pH 7.4 at 25 °C.
Forma física
Supplied as a solution in 50 mM Tris-HCl pH 7.5, and 50% glycerol
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
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