SAB4504190
Anti-phospho-HDAC6 (pSer22) antibody produced in rabbit
affinity isolated antibody
Sinónimos:
Anti-CPBHM, Anti-HD6, Anti-JM21, Anti-PPP1R90
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
antigen 131 kDa
reactividad de especies
human, rat, mouse
concentración
~1 mg/mL
técnicas
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer22)
Información sobre el gen
human ... HDAC6(10013)
Descripción general
Histone deacetylases 6 (HDAC6) is encoded by the gene mapped to human chromosome Xp11.23. It belongs to the class IIb histone deacetylase family of enzymes, that remove acetyl groups from lysine residues. This protein is present mainly in cytosol.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22.
Immunogen Range: 7-56
Immunogen Range: 7-56
Acciones bioquímicas o fisiológicas
Histone deacetylases 6 (HDAC6) is associated with various cellular processes such as regulation of microtubules, growth factor-induced chemotaxis, misfolded protein stress response, and tumor invasion. Increased expression of HDAC6 might promote tumorigenesis by upregulating the expression of c-myc. Overexpression of HDAC6 is seen in acute myeloid leukemia and some breast cancer patients. Oncogenic K-ras imparts suberoylanilide hydroxamic acid (SAHA) resistance via increasing HDAC6 and c-myc expression. HDAC6 controls cellular protective response against cytotoxic accumulation of toxic bioproducts. HDAC6 Inhibition is considered to be a potential therapeutic strategy for treating inflammatory breast cancer (IBC) patients. HDAC6 and acetylated α-tubulin play a vital role in regulation of adipocyte differentiation.
Características y beneficios
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Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
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The catalytically inactive mitogen-activated protein (MAP) kinase phosphatase, MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) interacts with the stress granule nucleator G3BP-1 (Ras-GAP (GTPase-activating protein) SH3 (Src homology 3) domain-binding protein-1), and decreases stress granule (stalled mRNA) formation. Histone deacetylase
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