SAB4300644

Anti-TAZ antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-WWTR1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: buffered aqueous solution
• mol peso: ~49 kDa
• reactividad de especies: rat, human, mouse
• concentración: 1 mg/mL
• técnicas: western blot: 1:500-1:1000
• isotipo: IgG
• secuencia del inmunógeno: (V-E-S-A-L)
• Nº de acceso NCBI: NM_001168278.1
• Nº de acceso UniProt: Q16635
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TAZ(25937)

Descripción

Descripción general

The antibody detects endogenous level of total TAZ protein.

Inmunógeno

Peptide sequence around aa. 386-390 (V-E-S-A-L), according to the protein NP_001161750.1

Características y beneficios

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Descripción de destino

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable