SAB3500666

Anti-TRMT12 antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• mol peso: 49 kDa
• reactividad de especies: human, mouse
• concentración: 1 mg/mL
• técnicas: ELISA: suitable; immunocytochemistry: suitable; western blot: suitable
• Nº de acceso UniProt: Q53H54
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TRMT12(55039)

Descripción

Descripción general

TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.

Inmunógeno

Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.

Acciones bioquímicas o fisiológicas

TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.

Características y beneficios

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Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500666.

Forma física

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable