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N3663

Sigma-Aldrich

Anti-NeuroD1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-BHF-1, Anti-NDF1, Anti-Neurogenic differentiation factor1

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About This Item

Número MDL:
MFCD03097085
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~45 kDa (doublet bands)

reactividad de especies

human, rat, mouse

envase

antibody small pack of 25 μL

concentración

~1 mg/mL

técnicas

western blot: 0.5-1 μg/mL using whole extracts of HEK-293T cells expressing human NeuroD1

Nº de acceso UniProt

Q13562

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... NEUROD1(4760)
mouse ... Neurod1(18012)
rat ... Neurod1(29458)

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Descripción general

NeuroD1 gene is mapped to human chromosome 2q31.3.
Neuronal differentiation 1 (NEUROD1) is a transcription factor which is highly expressed in the brain, pancreas and retina.

Especificidad

Anti-NeuroD1 specifically recognizes human, mouse and rat NeuroD1.

Inmunógeno

synthetic peptide corresponding to amino acids 76-91 of human NeuroD1 conjugated to BSA. The corresponding sequence differs in mouse and rat by two and three amino acids, respectively.

Aplicación

Anti-NeuroD1 antibody produced in rabbit has been used in chromatin immunoprecipitation and immunoblotting.

Acciones bioquímicas o fisiológicas

NeuroD1 is a basic helix-loop-helix (bHLH) transcription factor, which regulates the fate of specific neuronal, endocrine and retinal cells.
Neuronal differentiation 1 (NEUROD1) binds to promoters and regulates gene expression. It can also enhance tumor cell survival in lung tumors. Mutations in the gene encoding NEUROD1 have been associated with neurological problems and early-onset diabetes.

Forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Lack of association between NeuroD1/D6 gene polymorphism and heroin dependence in Han-chinese male population
Tsou CC, et al.
Journal of Medical Sciences, 38(5), 228-228 (2018)
Jihan K Osborne et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6524-6529 (2013-04-05)
Small-cell lung cancer and other aggressive neuroendocrine cancers are often associated with early dissemination and frequent metastases. We demonstrate that neurogenic differentiation 1 (NeuroD1) is a regulatory hub securing cross talk among survival and migratory-inducing signaling pathways in neuroendocrine lung
Winifred P S Wong et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13057-13062 (2010-07-10)
Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERalpha also enhances insulin synthesis in cultured islets. Whether ERalpha stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these
Feng Wang et al.
Investigative ophthalmology & visual science, 56(1), 150-155 (2014-12-06)
Mutations in the same gene can lead to different clinical phenotypes. In this study, we aim to identify novel genotype-phenotype correlations and novel disease genes by analyzing an unsolved autosomal recessive retinitis pigmentosa (ARRP) Han Chinese family. Whole exome sequencing

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