M168

Methyllycaconitine citrate salt

From Delphinium brownii seeds, ≥96% (HPLC), α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist

• Sinónimos: MLA, [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt
• Fórmula empírica (notación de Hill): C₃₇H₅₀N₂O₁₀ · xC₆H₈O₇
• Número CAS: 112825-05-5
• Peso molecular: 682.80 (salt-free basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896681
• NACRES: NA.77
• MDL number: MFCD00153837
• Assay: ≥96% (HPLC)

Propiedades

• Nombre del producto: Methyllycaconitine citrate salt, from Delphinium brownii seeds, ≥96% (HPLC)
• biological source: Delphinium brownii seeds
• Quality Segment: 100
• assay: ≥96% (HPLC)
• color: white
• solubility: H₂O: 42 mg/mL
• storage temp.: −20°C
• SMILES string: O=C(OC[C@]12[C@@]([C@]3([C@H](CC1)OC)[C@@H]4N(C2)CC)([H])[C@@H]([C@]4(O)[C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)OC)C7=CC=CC=C7N8C([C@@H](C)CC8=O)=O.OC(CC(CC(O)=O)(C(O)=O)O)=O
• InChI: 1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1
• InChI key: INBLZNJHDLEWPS-DDIMIZGISA-N

Descripción

Application

Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:

• to study its effects on inflammatory response in rats post nicotine treatment[1]
• to block the activity of galantamine[2]
• to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats[3]

Biochem/physiol Actions

Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium.[4] MLA binds to the binding site of neuronal α-bungarotoxin.[5] Low doses of MLA are associated with improvement of cognition in animals.[4]

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)