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L3794

Sigma-Aldrich

LOK (1-348), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

PRO2729, STK10

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

Nivel de calidad

100

Línea del producto

PRECISIO® Kinase

Análisis

≥70% (SDS-PAGE)

formulario

buffered aqueous glycerol solution

actividad específica

2-4 nmol/min·mg

mol peso

~65 kDa

Nº de acceso UniProt

O94804

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... STK10(6793)

Descripción general

LOK (lymphocyte-oriented kinase) belongs to the Ste20 (sterile 20) family of serine/threonine kinases. It is expressed in lymphocytes, brain, colon, thymus, kidney, liver, small intestine and lung. LOK is commonly referred to as STK10 (serine/threonine protein kinase 10).

Acciones bioquímicas o fisiológicas

Mutations in LOK (lymphocyte-oriented kinase) are linked with the anti-apoptotic effects leading to carcinogenesis. It functions as an ERM (ezrin-radixin-moesin) kinase and thereby regulates cytoskeletal organization and lymphocyte migration. It can phosphorylate PLK1 (polo-like kinase 1).

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Información legal

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kazutaka Fukumura et al.
Oncology reports, 30(4), 1542-1548 (2013-07-12)
Peripheral T-cell lymphoma (PTCL) is an aggressive lymphoma with a 5-year overall survival rate of <30%. To identify carcinogenesis-related genes in PTCL, we conducted high-throughput resequencing of target-captured cDNA in a PTCL specimen, revealing a total of 19 missense mutations
Sarah A Walter et al.
The Journal of biological chemistry, 278(20), 18221-18228 (2003-03-18)
The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. We have identified a previously cloned but uncharacterized family member termed Stk10, which is a human homolog of murine Lok
Natalya V Belkina et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(12), 4707-4712 (2009-03-04)
ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells. ERM activity is regulated in part by phosphorylation at a C-terminal threonine, but the identity of ERM kinases is unknown in lymphocytes and incompletely defined in
Li Tao et al.
The Biochemical journal, 363(Pt 1), 175-182 (2002-03-21)
T-cell activation requires signals from both the T-cell receptor (TcR) and other co-stimulatory molecules such as CD28. TcR- and CD28-mediated signals are integrated during T-cell activation resulting in the expression of cytokine genes such as interleukin-2 (IL-2). An enhancer element

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