E8034
Monoclonal Anti-EEA1 antibody produced in mouse
~1.0 mg/mL, clone EEA1-C33, purified immunoglobulin, buffered aqueous solution
Sinónimos:
Anti-Early endosomal antigen 1, Anti-MST105, Anti-MSTP105, Anti-ZFYVE2
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About This Item
Código UNSPSC:
12352203
origen biológico
mouse
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
EEA1-C33, monoclonal
Formulario
buffered aqueous solution
mol peso
antigen ~160 kDa
reactividad de especies
human, mouse, rat
concentración
~1.0 mg/mL
técnicas
western blot: 2-4 μg/mL using whole extract of rat NRK or human HeLa cells
isotipo
IgG1
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... EEA1(8411)
mouse ... Eea1(216238)
rat ... Eea1(314764)
Descripción general
The gene Early Endosome Antigen 1 (EEA1) encodes for around 1400 amino acid proteins. It is a peripheral membrane protein associated with the cytoplasmic face of early endosomes. EEA1 is a autoantigen associated with subacute cutaneous systemic lupus erythematosus and is a coiled-coil protein localized to early endosomes and cytosol.
Aplicación
Monoclonal Anti-EEA1 antibody produced in mouse is suitable for the following applications:
- Western blotting (at a concentration of 2-4μg/mL using whole extract of rat NRK or human HeLa cells)
- Immunofluorescence Analysis
- Immunocytochemistry
Acciones bioquímicas o fisiológicas
Early Endosome Antigen 1 (EEA1) controls vesicle fusion during endocytosis. In neurons, it is involved in recycling of synaptic vesicles and neurotransmitter receptors. Patients with neurological deficits develop EEA1 autoantibodies. Mutation in EEA1 gene leads to susceptibility to diabetes in the Japanese population. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is essential for the localization and function of EEA1.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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