D3070
Anti-DCDC2 (C-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-DCDC2A, Anti-RU2, Anti-RU2S
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
buffered aqueous solution
mol peso
antigen ~55 kDa
antigen ~70 kDa
reactividad de especies
human
validación mejorada
recombinant expression
Learn more about Antibody Enhanced Validation
concentración
~1.5 mg/mL
técnicas
western blot: 0.5-1 μg/mL using HEK-293T cell lysate expressing human DCDC2
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... DCDC2(51473)
Descripción general
Doublecortin domain-containing protein 2 (DCDC2) belongs to the doublecortin (DCX) superfamily and contains two doublecortin domains. DCDC2 is expressed in the fetal and adult central nervous system (CNS). DCDC2 gene is mapped to human chromosome 6p22.3.
Especificidad
Anti-DCDC2 (C-terminal) specifically recognizes human DCDC2.
Aplicación
Anti-DCDC2 antibody produced in rabbit is suitable for western blot analysis at a working concentration of 0.5-1μg/mL using a HEK-293T cell lysate expressing human DCDC2.
Acciones bioquímicas o fisiológicas
DCDC2 is one of the dyslexia susceptibility genes involved in neuronal migration and other developmental processes. The DCX domain of DCDC2 binds tubulin and enhances microtubule polymerization. Several SNPs within the DCDC2 gene have been associated with dyslexia. It modulates neuronal development in the brain.
Mutations in the DCDC2 gene is implicated in non-syndromic recessive deafness DFNB66 neonatal sclerosing cholangitis (NSC) and renal-hepatic ciliopathy.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Almacenamiento y estabilidad
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Precios
Código de clase de almacenamiento
10 - Combustible liquids
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Yuxiang Lin et al.
Clinics and research in hepatology and gastroenterology, 44(5), e103-e108 (2020-03-25)
Neonatal sclerosing cholangitis (NSC) is a severe cholestatic liver disease, which often develops into end-stage liver disease in childhood and requires liver transplantation. Mutations in CLDN1 and DCDC2 are confirmed to be the main pathogenic mechanism of NSC. Whole exon
Orly Reiner et al.
BMC genomics, 7, 188-188 (2006-07-28)
Doublecortin (DCX) domains serve as protein-interaction platforms. Mutations in members of this protein superfamily are linked to several genetic diseases. Mutations in the human DCX gene result in abnormal neuronal migration, epilepsy, and mental retardation; mutations in RP1 are associated
Lauren M McGrath et al.
Trends in molecular medicine, 12(7), 333-341 (2006-06-20)
Four genes have recently been proposed as candidates for dyslexia: dyslexia susceptibility 1 candidate 1 (DYX1C1), roundabout Drosophila homolog 1 (ROBO1), doublecortin domain-containing protein 2 (DCDC2) and KIAA0319. Each gene is implicated in global brain-development processes such as neural migration
Johannes Schumacher et al.
American journal of human genetics, 78(1), 52-62 (2005-12-31)
We searched for linkage disequilibrium (LD) in 137 triads with dyslexia, using markers that span the most-replicated dyslexia susceptibility region on 6p21-p22, and found association between the disease and markers within the VMP/DCDC2/KAAG1 locus. Detailed refinement of the LD region
Markus Schueler et al.
American journal of human genetics, 96(1), 81-92 (2015-01-06)
Nephronophthisis-related ciliopathies (NPHP-RC) are recessive diseases characterized by renal dysplasia or degeneration. We here identify mutations of DCDC2 as causing a renal-hepatic ciliopathy. DCDC2 localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner. Knockdown of
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