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A1486

Sigma-Aldrich

Anti-ATP6AP1 (451-465) antibody produced in rabbit

IgG fraction of antiserum, PBS solution

Sinónimos:

Anti-16A, Anti-ATP6IP1, Anti-ATP6S1, Anti-Ac45, Anti-CF2, Anti-VATPS1, Anti-Vacuolar ATP synthase subunit S1 precursor, Anti-XAP3

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

PBS solution

mol peso

antigen ~52 kDa

reactividad de especies

human

técnicas

western blot: 1:500-1:2,000

Nº de acceso UniProt

Q15904

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ATP6AP1(537)

Descripción general

ATPase H+ transporting accessory protein 1 (ATP6AP1) is an accessory subunit of the V-ATPase. This gene is located on human chromosome Xq28. ATP6AP1 is also referred as Ac45. It is abundantly expressed a high levels in neuronal and (neuro-) endocrine cells and osteoclasts.

Inmunógeno

synthetic peptide corresponding to amino acids 451-465 of human ATP6AP1

Aplicación

Rabbit anti-ATP6AP1 (451-465) antibody can be used for western blot (1:500-1:2,000) assays.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Acciones bioquímicas o fisiológicas

ATPase H+ transporting accessory protein 1 (ATP6AP1) is known to cause an X-linked N-glycosylation syndrome with liver disease. It is essential for endosomal acidification. It also participates in membrane trafficking and Ca2+-dependent membrane fusion.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Expanding the phenotype of metabolic cutis laxa with an additional disorder of N-linked protein glycosylation
Witters P, et al.
European Journal of Human Genetics, 26(5), 618-618 (2018)
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
Pareja F, et al.
Nature Communications, 9(1), 3533-3533 (2018)
Jason J Gokey et al.
Developmental biology, 407(1), 115-130 (2015-08-09)
Asymmetric fluid flows generated by motile cilia in a transient 'organ of asymmetry' are involved in establishing the left-right (LR) body axis during embryonic development. The vacuolar-type H(+)-ATPase (V-ATPase) proton pump has been identified as an early factor in the
Fresia Pareja et al.
Nature communications, 9(1), 3533-3533 (2018-09-01)
Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The genetic drivers of GCTs are currently unknown. Here, we apply whole-exome sequencing and targeted sequencing analysis to reveal

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