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Merck

403A-7

C3d Rabbit Polyclonal Antibody

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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
4

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biological source

rabbit

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (403A-74), vial of 0.5 mL concentrate (403A-75), bottle of 1.0 mL predilute (403A-77), vial of 1.0 mL concentrate (403A-76), bottle of 7.0 mL predilute (403A-78)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Quality Level

Gene Information

human ... CR2(1380)

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1 of 4

Este artículo
404A-1404R-1MABF983
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

clone

polyclonal

clone

polyclonal

clone

SP91, monoclonal

clone

1H8, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human, primate

antibody form

Ig fraction of antiserum

antibody form

Ig fraction of antiserum

antibody form

culture supernatant

antibody form

purified immunoglobulin

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

General description

Complement component C3 is an integral part of the classical, lectin, and alternative complement pathways, and its cleavage products are involved in immune responses such as opsonization and cell lysis. C3d is a fragment of C3 that normally binds to pathogen surfaces to promote B-cell activation. However, deposition of C3d has also been observed in peritubular capillaries of transplanted kidneys undergoing acute allograft rejection.[1]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD

IVD

IVD

RUO

Other Notes

C3d Positive Control Slides, Product No. 403S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Dirk R J Kuypers et al.
Transplantation, 76(1), 102-108 (2003-07-17)
C4d deposition in peritubular capillaries (PTCs) is a sign of humoral renal allograft rejection and an independent predictor of graft survival. Few investigators have focused on the meaning of capillary C3 deposition in rejecting grafts. Because C3 production can result
Alice Bickerstaff et al.
The American journal of pathology, 173(2), 347-357 (2008-06-28)
Acute humoral rejection (AHR), which occurs in up to 8% of kidney transplant recipients, is a significant cause of renal allograft dysfunction and loss. More efficacious treatment modalities are needed to eliminate or curtail alloantibody production and its deleterious effects
G Eggertsen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 109(12), 825-834 (2002-02-16)
Among patients with early severe impairment of renal allograft function we have previously identified a group displaying isolated deposition of complement factor C3 in glomeruli. Here we studied the pattern of complement deposition more extensively in allograft biopsies from five
Katrin Pfaltz et al.
Journal of cutaneous pathology, 37(6), 654-658 (2009-10-30)
Direct immunofluorescence (DIF) testing is an important procedure in the diagnosis of autoimmune bullous dermatoses. We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses. The immunohistochemical expression of C3d in bullous pemphigoid (BP) (n =

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