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A7250

Sigma-Aldrich

N-Acetyl-L-cysteine

≥99% (TLC)

Sinónimos:

LNAC, NAC

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About This Item

Fórmula lineal:
HSCH2CH(NHCOCH3)CO2H
Número de CAS:
616-91-1
Peso molecular:
163.19
Beilstein:
1724426
Número CE:
210-498-3
Número MDL:
MFCD00004880
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24277970
NACRES:
NA.26

product name

N-Acetyl-L-cysteine, Sigma Grade, ≥99% (TLC), powder

grado

Sigma Grade

Nivel de calidad

200

Análisis

≥99% (TLC)

formulario

powder

color

white to off-white

mp

106-108 °C (lit.)

solubilidad

H2O: 100 mg/mL (with heating)

aplicaciones

cell analysis

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

Clave InChI

PWKSKIMOESPYIA-BYPYZUCNSA-N

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Aplicación

N-Acetyl-L-cysteine has been used to suppress oxygen-dependent hydroxyurea sensitivity in Saccharomyces cerevisiae. It has also been used as an antioxidant for the treatment of C2C12 murine myoblasts.

Acciones bioquímicas o fisiológicas

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Aplicación

Referencia del producto
Descripción
Precios

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Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H319

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificados de análisis (COA)

Lot/Batch Number
0000307691
0000307691
WXBF2668V
WXBF0722V
0000310431

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Loss of SOD1 and LYS7 Sensitizes Saccharomyces cerevisiae to Hydroxyurea and DNA Damage Agents and Downregulates MEC1 Pathway Effectors?
Carole D. Carter
Journal of Virology, 25(23), 10273-10285 (2005)
Low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in skeletal muscle
Madlyn I. Frisard
Metabolism and Disease, 64(3), 416-427 (2015)
Carolina Martinez Romão et al.
Life sciences, 231, 116544-116544 (2019-06-11)
To investigate the effect of long-term N-acetyl-l-cysteine (NAC) treatment in Wistar rats subjected to renal ischemia and reperfusion (IR) and a chronic high‑sodium diet (HSD). Adult male Wistar rats received an HSD (8.0% NaCl) or a normal‑sodium diet (NSD; 1.3%
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
Suzanne M Cloonan et al.
Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that
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