FCMAB250A4

Milli-Mark^® Anti-Bcl-2 Antibody, Alexa Fluor^™488, clone AW604

clone AW604, Milli-Mark^®, from mouse

• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: ALEXA FLUOR^™ 488
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: AW604, monoclonal
• reactividad de especies: human
• fabricante / nombre comercial: Milli-Mark^®
• técnicas: flow cytometry: suitable
• isotipo: IgG2a
• Nº de acceso NCBI: NP_000624
• Nº de acceso UniProt: P10415
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... BCL2(596)

Descripción

Descripción general

Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 also regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It appears to Inhibit caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Further understanding in how Bcl-2 functions and interacts with other proteins to promote or inhibit apoptosis may lead to new treatments for cancer, neurological disorders and autoimmune diseases.

Especificidad

Antibody recognizes Bcl-2.

Inmunógeno

KLH-conjugated, synthetic peptide corresponding to human Bcl-2

Aplicación

Research Category
Apoptosis & Cancer

Research Sub Category
BCL2 & Inhibition

This Milli-Mark Bcl-2 antibody is validated for use in Flow for the detection of the Milli-Mark Bcl-2 protein.

Calidad

Evaulated by flow cytometery using Jurkat cells.

Descripción de destino

26 kDa Calculated

Forma física

Protein G Purified

Purified mouse monoclonal IgG2a conjugated to Alexa Fluor^™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Almacenamiento y estabilidad

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Nota de análisis

Control
Jurkat Cells

Información legal

ALEXA FLUOR is a trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Alexa Fluor^™ is a registered trademark of Molecular Probes, Inc.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable