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5.00554

MHY1485

Name: MHY1485
Brand: MM
Price: 189 EUR

≥97% (HPLC), solid, mTOR activator, Calbiochem^®

Sinónimos:

mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III

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Tamaño de envase	SKU	Disponibilidad	Precio
10 mg		Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	189,00 €

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Fórmula empírica (notación de Hill):

C₁₇H₂₁N₇O₄

Número CAS:

326914-06-1

Peso molecular:

387.39

MDL number:

MFCD06591335

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

2026662

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

189,00 €

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Propiedades

Nombre del producto

mTOR Activator, MHY1485,

assay

≥97% (HPLC)

Quality Segment

100

form

solid

potency

~2 μM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 12.5 mg/mL

storage temp.

2-8°C

SMILES string

C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O

InChI key

VHYUALWDIXAVIZ-UHFFFAOYSA-N

Descripción

General description

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

Application

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Choi, Y. J., et al. 2012. PLoS. One.7, e43418.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Este artículo	475986	5.06048	475991
Sigma-Aldrich 5.00554 mTOR Activator, MHY1485	Sigma-Aldrich 475986 mTOR Kinase Inhibitor II, WYE-354	Sigma-Aldrich 5.06048 Beclin-1 Activator I, TAT-Beclin-1	Sigma-Aldrich 475991 mTOR Inhibitor XI, Torin1
form solid	form solid	form powder	form powder
assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥97% (HPLC)	assay ≥99% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 12.5 mg/mL	solubility DMSO: 50 mg/mL	solubility DMSO: 50 mg/mL, water: 50 mg/mL	solubility DMSO: 2 mg/mL

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c