07-413

Anti-dimethyl-Arginine Antibody, symmetric (SYM11)

Upstate^®, from rabbit

• Synonym(s): Anti-SYM11, Anti-dimethyl-Arginine, Symmetric Dimethyl-Arginine Ab
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Clone: polyclonal
• Species reactivity: human, mouse
• Application: WB
• Citations: 19

Properties

• biological source: rabbit
• Quality Segment: 100
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human, mouse
• manufacturer/tradename: Upstate^®
• technique(s): western blot: suitable
• isotype: IgG
• shipped in: dry ice
• target post-translational modification: unmodified

Description

General description

Symmetrical dimethylated arginine (sDMA) is a product of the post-translational modification, arginine methylation. sDMA is a structural isomer of asymmetric dimethylarginine.

~16 kDa

Immunogen

peptide corresponding to amino acids 99-119 of Small nuclear ribonucleoprotein SmD3.

Application

Anti-dimethyl-Arginine Antibody, symmetric (SYM11) has been used in:

• co-immunoprecipitation (co-IP)
• western blot analysis
• immunoprecipitation

Biochem/physiol Actions

SmD3 at ~16kDa, and other proteins that contain arginines that are symmetrically dimethylated

Symmetrical dimethylarginine (sDMA) is a competitor of arginine transport and is eliminated through renal excretion. sDMA serves as a marker to indicate the estimated glomerular filtration rate (GFR) and the coronary artery disease (CAD) severity. Elevated sDMA is associated with the risk of cardiovascular disease and mortality. It might also help in the early detection of chronic kidney disease. sDMA acts as an endogenous marker of renal function. It is associated with tumorigenesis.

Physical form

Format: Purified

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

routinely evaluated by immunoblot in RIPA lysates from Jurkat cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1