P-151

PEth 16:0/18:1-D₅ solution

100 μg/mL in methanol (as free phosphate), certified reference material, ampule of 1 mL, Cerilliant^®

• Fórmula empírica (notación de Hill): C₃₉H₆₉D₅O₈P · NC₃H₁₀
• Peso molecular: 767.12
• Código UNSPSC: 41116107
• NACRES: NA.24

Propiedades

• grado: certified reference material
• Nivel de calidad: 300
• formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 100 μg/mL in methanol (as free phosphate)
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: forensics and toxicology
• formato: single component solution
• temp. de almacenamiento: −70°C

Descripción

Descripción general

This stable-labeled internal standard is suitable for quantitation of PEth 16:0/18:1 in LC/MS or GC/MS applications. PEth 16:0/18:1, also known as phosphatidylethanol 16:0/18:1, is a sensitive and specific biomarker for alcohol use and abuse. Since the detection window of PEth 16:0/18:1 in blood is longer than that of ethyl glucuronide (EtG) or ethyl sulfate (EtS) in urine, measurement of blood PEth 16:0/18:1 level is routinely performed in clinical toxicology and forensic testing applications such as abstinence monitoring and workplace drug testing. PEth 16:0/18:1 has also been investigated as a biomarker to confirm prenatal alcohol exposure (PAE).

Aplicación

• Validation of LC-MS/MS method for erythrocyte phosphatidylethanol: A recent study validated a liquid chromatography tandem mass spectrometry method for erythrocyte phosphatidylethanol (PEth), utilizing the PEth 16:0/18:1-D₅ internal standard. This research highlights critical considerations for using PEth as a reliable clinical biomarker of alcohol consumption, proving essential for advancements in biochemical research reagents and methodology (White et al., 2022).

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P260 - P280 - P301 + P310 + P330 - P308 + P311 - P370 + P378 - P403 + P233
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órganos de actuación: Eyes
• Código de clase de almacenamiento: 3 - Flammable liquids
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup