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Merck

XBP1

X-box binding protein 1

Sinónimos:
TREB5, XBP-1, XBP2
Especie:
Human XBP1 (7494), Mouse Xbp1 (22433), Rat Xbp1 (289754), Zebrafish xbp1 (140614), fruit fly Xbp1 (44226), chicken XBP1 (416918), dog XBP1 (477532), cow XBP1 (541236)
ID UniProtKB:
P17861, Q8WYK6, Q969P1, Q96BD7
ID del gen:
  • Human(7494) Summary: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
  • Mouse(22433) X-box binding protein 1
  • Rat(289754) X-box binding protein 1
  • Zebrafish(140614) X-box binding protein 1
  • fruit fly(44226) X box binding protein-1
  • chicken(416918) X-box binding protein 1
  • dog(477532) X-box binding protein 1
  • cow(541236) X-box binding protein 1

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
MABC521
Anticuerpo anti-XBP1, clon 143F (forma activa), clone 143F, from mouse,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
SAB5700758
Anti-XBP1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
western blot
SAB2102720
Anti-XBP1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
bovine, human
Aplicación
western blot
SAB3500381
Anti-XBP-1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunocytochemistry
western blot
WH0007494M1
Monoclonal Anti-XBP1 antibody produced in mouse, clone 3F5, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunofluorescence
western blot

esiRNA

Referencia del producto
Descripción
Especie
EHU069131
MISSION® esiRNA, targeting human XBP1,
Especie
human
EMU050031
MISSION® esiRNA, targeting mouse Xbp1,
Especie
mouse