Saltar al contenido
Merck

UPF3B

UPF3 regulator of nonsense transcripts homolog B (yeast)

Sinónimos:
HUPF3B, MRXS14, RENT3B, UPF3X
Especie:
ID UniProtKB:
ID del gen:
  • Human(65109) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(68134) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • Rat(313449) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • domestic cat(101084940) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • cow(616181) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • naked mole-rat(101700790) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • Zebrafish(393929) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • dog(481031) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • chicken(100858231) UPF3 regulator of nonsense transcripts homolog B (yeast)
  • sheep(101101868) UPF3 regulator of nonsense transcripts homolog B (yeast)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-UPF3B antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-UPF3B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
Anti-UPF3B, from rabbit,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-UPF3B antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry

western blot

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Upf3b,
Especie
mouse
MISSION® esiRNA, targeting human UPF3B,
Especie
human