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Merck

TNNI1

troponin I type 1 (skeletal, slow)

Sinónimos:
SSTNI, TNN1
Especie:
ID UniProtKB:
ID del gen:
  • Human(7135) Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
  • Mouse(21952) troponin I, skeletal, slow 1
  • Rat(29388) troponin I type 1 (skeletal, slow)
  • chicken(421161) troponin I type 1 (skeletal, slow)
  • cow(100301375) troponin I type 1 (skeletal, slow)
  • dog(100685160) troponin I type 1 (skeletal, slow)
  • Goat(100860774) troponin I type 1 (skeletal, slow)
  • domestic guinea pig(100733717) troponin I type 1 (skeletal, slow)
  • domestic cat(101096197) troponin I type 1 (skeletal, slow)
  • naked mole-rat(101720739) troponin I type 1 (skeletal, slow)

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-TNNI1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-TNNI1 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Reactividad de especies
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat
Aplicación
western blot
Anti-TNNI1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-Troponin I1/TnI1 Antibody, clone 5K1U2, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot

Proteins

Referencia del producto
Descripción
Especie
Troponin1, His tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse TNNI1,
Especie
mouse
MISSION® esiRNA, targeting human TNNI1,
Especie
human