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Merck

PTPN1

protein tyrosine phosphatase, non-receptor type 1

Sinónimos:
PTP1B
Especie:
Human PTPN1 (5770), Mouse Ptpn1 (19246), Rat Ptpn1 (24697), chicken PTPN1 (395688), Zebrafish ptpn1 (30081), cow PTPN1 (508658), Domestic Rabbit PTPN1 (100354834), Horse PTPN1 (100052066), domestic cat PTPN1 (101099626), dog PTPN1 (477263) ...Más
ID UniProtKB:
P18031, Q5TGD8, Q9BQV9, Q9NQQ4
ID del gen:
  • Human(5770) Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
  • Mouse(19246) protein tyrosine phosphatase, non-receptor type 1
  • Rat(24697) protein tyrosine phosphatase, non-receptor type 1
  • chicken(395688) protein tyrosine phosphatase, non-receptor type 1
  • Zebrafish(30081) protein tyrosine phosphatase, non-receptor type 1
  • cow(508658) protein tyrosine phosphatase, non-receptor type 1
  • Domestic Rabbit(100354834) protein tyrosine phosphatase, non-receptor type 1
  • Horse(100052066) protein tyrosine phosphatase, non-receptor type 1
  • domestic cat(101099626) protein tyrosine phosphatase, non-receptor type 1
  • dog(477263) protein tyrosine phosphatase, non-receptor type 1
  • naked mole-rat(101696680) protein tyrosine phosphatase, non-receptor type 1
  • domestic guinea pig(100730699) protein tyrosine phosphatase, non-receptor type 1
  • sheep(101118209) protein tyrosine phosphatase, non-receptor type 1

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ELISA

Referencia del producto
Descripción
Especie
RAB1657
Human PTP1B ELISA, for serum, plasma and cell culture supernatants,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
MABS456
Anti-PTP1B Antibody (Oxidized), clone scFvs 45, clone scFvs 45, from chicken,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
HPA012542
Anti-PTPN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
MABS197
Anti-PTP1B Antibody, clone FG6-1G, clone FG6-1G, from mouse,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot
SAB4301535
Anti-phospho-PTP1B (pSer50) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, monkey, mouse, rat
Aplicación
western blot
SAB4502525
Anti-PTP1B antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
A79604
4-Aminosalicylic acid, 99%,
Especie
human
C85603
Coumarin-3-carboxylic acid, 99%,
Especie
human
301353
2,6-Naphthalenedicarboxylic acid, 95%,
Especie
human
523763
2,6-Naphthalenedicarboxylic acid, 99%,
Especie
human
383449
3-Formylchromone, 97%,
Especie
human

Kits

Referencia del producto
Descripción
Especie
17-125
PTP Assay Kit 1, PTP Assay Kit 1 can be used to detect PTP-1B activity by dephosphorylation of the phosphopeptide (RRLIEDAEpYAARG) using malachite green detection, or by hydrolysis of pNPP.,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
SRP0212
PTP1B (1-321)/PTPN1 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Especie
human
P6244
Protein Tyrosine Phosphatase 1B human, recombinant, expressed in E. coli,
Especie
human
SRP0215
PTP1B full length Active human, recombinant, expressed in E. coli, aqueous solution, ≥55% (SDS-PAGE),
Especie
human
SRP0213
PTP1B (1-321)/PTPN1 Active from mouse, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Especie
human
SRP5071
PTPN1, active, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU016451
MISSION® esiRNA, targeting human PTPN1,
Especie
human
EMU061791
MISSION® esiRNA, targeting mouse Ptpn1,
Especie
mouse