PIKFYVE
phosphoinositide kinase, FYVE finger containing
Sinónimos:
CFD, FAB1, PIP5K, PIP5K3, ZFYVE29
Especie:
Human PIKFYVE (200576), Mouse Pikfyve (18711), Rat Pikfyve (316457), naked mole-rat Pikfyve (101705294), domestic guinea pig Pikfyve (101788192), dog PIKFYVE (478890), cow PIKFYVE (790873), Horse PIKFYVE (100066445), sheep PIKFYVE (101120727), Zebrafish pikfyve (337690) ...Más
ID UniProtKB:
ID del gen:
- Human(200576) Summary: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
- Mouse(18711) phosphoinositide kinase, FYVE finger containing
- Rat(316457) phosphoinositide kinase, FYVE finger containing
- naked mole-rat(101705294) phosphoinositide kinase, FYVE finger containing
- domestic guinea pig(101788192) phosphoinositide kinase, FYVE finger containing
- dog(478890) phosphoinositide kinase, FYVE finger containing
- cow(790873) phosphoinositide kinase, FYVE finger containing
- Horse(100066445) phosphoinositide kinase, FYVE finger containing
- sheep(101120727) phosphoinositide kinase, FYVE finger containing
- Zebrafish(337690) phosphoinositide kinase, FYVE finger containing
- chicken(424114) phosphoinositide kinase, FYVE finger containing
- domestic cat(101094121) phosphoinositide kinase, FYVE finger containing
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-PIKFYVE, clon R159.4.3C9, clone R159.4.3C9, from mouse,
Reactividad de especies
human
Aplicación
western blot
Anti-PIKFYV antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-PIP5K antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-PIKFYVE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-PIP5K3 Mouse mAb (6C7), liquid, clone 6C7, Calbiochem®,
Reactividad de especies
human
Aplicación
esiRNA
Referencia del producto
Descripción
Especie