MAP2K3
mitogen-activated protein kinase kinase 3
Sinónimos:
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
Especie:
Human MAP2K3 (5606), Mouse Map2k3 (26397), Rat Map2k3 (303200), cow MAP2K3 (516039), domestic cat MAP2K3 (101082274), sheep MAP2K3 (101122959), Horse MAP2K3 (100053481), domestic guinea pig Map2k3 (100726100), chicken MAP2K3 (416496), dog MAP2K3 (489547)
ID UniProtKB:
ID del gen:
- Human(5606) Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
- Mouse(26397) mitogen-activated protein kinase kinase 3
- Rat(303200) mitogen activated protein kinase kinase 3
- cow(516039) mitogen-activated protein kinase kinase 3
- domestic cat(101082274) mitogen-activated protein kinase kinase 3
- sheep(101122959) mitogen-activated protein kinase kinase 3
- Horse(100053481) mitogen-activated protein kinase kinase 3
- domestic guinea pig(100726100) mitogen-activated protein kinase kinase 3
- chicken(416496) mitogen-activated protein kinase kinase 3
- dog(489547) mitogen-activated protein kinase kinase 3
- naked mole-rat(101718318) mitogen-activated protein kinase kinase 3
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-phospho-MAP2K3 (pThr222) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Monoclonal Anti-MAP2K3 antibody produced in mouse, clone 2F12, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
western blot
western blot
Monoclonal Anti-MAP2K3, (N-terminal) antibody produced in mouse, clone 1D10, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-MAP2K3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
Anti-MEK3/MEK6 Antibody, clone 8R1J5, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot
Small Molecule - Inhibitor
Referencia del producto
Descripción
Especie