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Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Sinónimos:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Especie:
ID UniProtKB:
ID del gen:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2

Custom & Knockdown Gene Products

Small Molecule - Agonist

Número de producto
Descripción
Especie
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Baclofen, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Especie
human
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Especie
human
(±)-Baclofen, ≥98% (HPLC), solid,
Especie
human, rat

Small Molecule - Allosteric Modulator

Número de producto
Descripción
Especie
CGP-13501, ≥98% (HPLC), solid,
Especie
human

Small Molecule - Antagonist

Número de producto
Descripción
Especie
2-Hydroxysaclofen, ≥98% (TLC), solid,
Especie
human
Phaclofen, solid,
Especie
human
(±)-Baclofen, ≥98% (HPLC), solid,
Especie
human, rat
Saclofen, solid,
Especie
mouse, human, rat
γ-Aminobutyric acid, ≥99%,
Especie
human, rat

Antibodies

Número de producto
Descripción
Reactividad de especies
Aplicación
Anti GABBR2 Antibody, clone 23GB5500, Rabbit Monoclonal, clone 23GB5500, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reactividad de especies
human, rat
Aplicación
western blot
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
Reactividad de especies
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Aplicación
immunohistochemistry
western blot
Anti-GABAB Receptor 2 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reactividad de especies
rat
Aplicación
western blot
Monoclonal Anti-Gaba-B Receptor 2 - Rpe antibody produced in mouse, clone S81-2, purified immunoglobulin,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunohistochemistry

western blot
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry

Small Molecule - Inhibitor

Número de producto
Descripción
Especie
NO-711 hydrochloride, ≥98% (HPLC),
Especie
human
(±)-Vigabatrin, ,
Especie
human

esiRNA

Número de producto
Descripción
Especie
MISSION® esiRNA, targeting human GABBR2,
Especie
human