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Merck

DUSP4

dual specificity phosphatase 4

Sinónimos:
HVH2, MKP-2, MKP2, TYP
Especie:
Human DUSP4 (1846), Mouse Dusp4 (319520), Rat Dusp4 (60587), domestic guinea pig Dusp4 (100728293), cow DUSP4 (540380), domestic cat DUSP4 (101088832), Domestic Rabbit DUSP4 (100351542), sheep DUSP4 (101103535), chicken DUSP4 (395642), Zebrafish dusp4 (394146)
ID UniProtKB:
Q13115, B2RBU5, D3DSU4, G5E930, Q13524
ID del gen:
  • Human(1846) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(319520) dual specificity phosphatase 4
  • Rat(60587) dual specificity phosphatase 4
  • domestic guinea pig(100728293) dual specificity phosphatase 4
  • cow(540380) dual specificity phosphatase 4
  • domestic cat(101088832) dual specificity phosphatase 4
  • Domestic Rabbit(100351542) dual specificity phosphatase 4
  • sheep(101103535) dual specificity phosphatase 4
  • chicken(395642) dual specificity phosphatase 4
  • Zebrafish(394146) dual specificity phosphatase 4
  • dog(482880) dual specificity phosphatase 4

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA077183
Anti-Dusp4 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
HPA061967
Anti-DUSP4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
SAB4301445
Anti-phospho-MKP-1/2 (pSer296/318) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
western blot

esiRNA

Referencia del producto
Descripción
Especie
EHU059741
MISSION® esiRNA, targeting human DUSP4,
Especie
human
EMU041791
MISSION® esiRNA, targeting mouse Dusp4,
Especie
mouse