BRCA2
breast cancer 2, early onset
Sinónimos:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
Especie:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...Más
ID UniProtKB:
ID del gen:
- Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
- Mouse(12190) breast cancer 2
- Rat(360254) breast cancer 2, early onset
- domestic guinea pig(100713136) breast cancer 2, early onset
- Zebrafish(566758) breast cancer 2, early onset
- naked mole-rat(101698015) breast cancer 2, early onset
- chicken(374139) breast cancer 2, early onset
- sheep(101109980) breast cancer 2, early onset
- fruit fly(37916) Breast cancer 2, early onset homolog
- cow(507069) breast cancer 2, early onset
- dog(474180) breast cancer 2, early onset
- domestic cat(493878) breast cancer 2, early onset
- Horse(100064578) breast cancer 2, early onset
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-BRCA2 (Ab-1) Mouse mAb (2B), liquid, clone 2B, Calbiochem®,
Reactividad de especies
human
Aplicación
Anti-BRCA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-BRCA2 Antibody, clone 1H2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-BRCA2 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, rat
Aplicación
ELISA
immunohistochemistry
immunohistochemistry
Anti-BRCA2 Antibody, clone 5.23, clone 5.23, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
western blot
western blot