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  • Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives.

Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (1999-10-29)
G M Williams, M J Iatropoulos, J Whysner
PMID10541460
ABSTRACT

Butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are widely used antioxidant food additives. They have been extensively studied for potential toxicities. This review details experimental studies of genotoxicity and carcinogenicity which bear on cancer hazard assessment of exposure to humans. We conclude that BHA and BHT pose no cancer hazard and, to the contrary, may be anticarcinogenic at current levels of food additive use.

MATERIALS
Product Number
Brand
Product Description
PHR1117
Supelco
Butylated Hydroxytoluene, Pharmaceutical Secondary Standard; Certified Reference Material
W218405
Sigma-Aldrich
Butylated hydroxytoluene, ≥99%, FCC, FG
1082708
USP
Butylated hydroxytoluene, United States Pharmacopeia (USP) Reference Standard
B1212000
Butylhydroxyanisole, European Pharmacopoeia (EP) Reference Standard
PHR1304
Supelco
Butylated hydroxyanisole, Pharmaceutical Secondary Standard; Certified Reference Material
78943
Supelco
Butylated hydroxyanisole, analytical standard
03762
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, tested according to Ph. Eur.
34750
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, purum, ≥99.0% (GC)
47168
Supelco
3,5-Di-tert-butyl-4-hydroxytoluene, analytical standard
W218308
Sigma-Aldrich
Butylated hydroxyanisole, 99%, FCC, FG
B1378
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylphenol, ≥99.0% (GC), powder
B1253
Sigma-Aldrich
Butylated hydroxyanisole, ≥98.5%
B1215000
Butylhydroxytoluene, European Pharmacopoeia (EP) Reference Standard