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  • Treatment with SI000413, a new herbal formula, ameliorates murine collagen-induced arthritis.

Treatment with SI000413, a new herbal formula, ameliorates murine collagen-induced arthritis.

Biological & pharmaceutical bulletin (2008-07-02)
Jee-Hun Park, Jeong-Min Lee, Se-Na Kim, Seung-Ha Lee, Sung-Hoon Jun, Jae-Hoon You, Kyoo-Seok Ahn, Hee Kang
ABSTRACT

We tested the effects of SI000413, a new formula, consisting of Pyrolae herba and Trachelospermi caulis, on type II collagen-induced arthritis (CIA). CIA was induced in DBA/1J mice by immunization with bovine type II collagen (CII) on days 1 and 21. SI000413 was orally administered 3 times per week throughout the experiment and indomethacin was served as a positive control. Clinical scores, the count of arthritic legs, levels of interleukin 6 (IL-6) and anti-CII antibody, and lymphocyte subsets in blood were examined. SI000413 suppressed CIA development in a dose dependent manner and reduced the incidence of arthritic legs in mice. Histological analysis showed administration of SI000413 reduced inflammatory signs and cartilage destruction. Serum levels of IL-6 and anti-CII antibody were significantly decreased in SI000413-treated mice and the percentages of CD4 T cell, CD8 T cell and B cell in blood were restored to normal levels. In conclusion, we demonstrate that SI000413 ameliorates CIA both clinically and histologically and inhibits the production of anti-CII antibody and pro-inflammatory cytokine in the CIA mouse. These findings suggest that SI000413 is a potential new therapeutic herbal formula for the treatment of RA.

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Arctiin, ≥95% (LC/MS-ELSD)
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