Conversion of indanone oximes into isocarbostyrils.

Conversion of indanone oximes into isocarbostyrils.

Bioorganic & medicinal chemistry letters (2006-10-27)

Yasuhiro Torisawa, Shinji Aki, Jun-ichi Minamikawa

ABSTRACT

New and effective method for the Beckmann rearrangement of indanone oxime mesylate is described, in which a selective and controlled production of the isomeric isocarbostyrils is achieved.

MATERIALS

Product Number

Brand

Product Description

64270

Sigma-Aldrich

Methanesulfonyl chloride, purum, ≥98.0% (AT)

152102

Sigma-Aldrich

Isocarbostyril, 98%

471259

Sigma-Aldrich

Methanesulfonyl chloride, ≥99.7%