SAB2501651

Anti-CREB3L1 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): BBF-2 (Drosophila) homolog, CAMP responsive element binding protein 3-like 1, Old astrocyte specifically induced substance
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: Q96BA8
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CREB3L1(90993)

Description

General description

Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) belongs to the CREB family of transcription factors. It has a bZIP (basic-leucine zipper) domain and a DNA binding domain. The gene encoding this protein is mapped to human chromosome 11 and is expressed in many tissues.

Immunogen

Peptide with sequence DFSHSKEWFHDRD, from the C-terminal region of the protein sequence according to NP_443086.1

Biochem/physiol Actions

Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) is an unfolded protein response (UPR) transducer. It localizes in the endoplasmic reticulum. In the presence of UPR signaling, CREB3L1 is cleaved and the amino terminal part is translocated to the nucleus. The nuclear part regulates target gene expression. CREB3L1 is involved in the differentiation and development of astrocytes, osteoblasts, odontoblasts, pancreatic beta-cells and large intestine goblet cells.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable