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H4025

Sigma-Aldrich

15α-Hydroxytestosterone

Synonym(s):

4-Androstene-15α,17β-diol-3-one

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About This Item

Empirical Formula (Hill Notation):
C19H28O3
CAS Number:
Molecular Weight:
304.42
MDL number:
UNSPSC Code:
12352200

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1[C@@H](O)C[C@@H]2O

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N Harada et al.
The Journal of biological chemistry, 259(2), 1265-1271 (1984-01-25)
Testosterone 15 alpha-hydroxylase (cytochrome P-450(15) alpha) was purified from female 129/J mouse liver microsomes based on its specific activities in the eluates from the columns of octylamino-Sepharose 4B, hydroxylapatite, DEAE-Bio-Gel A, and CM52 chromatography. The 15 alpha-hydroxylation activity was five
Bradley A Young et al.
General and comparative endocrinology, 136(2), 276-281 (2004-03-19)
The sea lamprey (Petromyzon marinus L.) represents one of the two most ancient classes of vertebrates and possesses a functional hypothalamus-pituitary-gonadal axis. However, the presence and functionality of androgens in the sea lamprey remain elusive. Recently, 15alpha-hydroxytestosterone (15alpha-T) has been
Mara B Bryan et al.
General and comparative endocrinology, 132(3), 418-426 (2003-07-10)
Prior research has shown that the testes of lampreys are able to synthesize 15-hydroxylated steroid hormones in vitro. Here we show that testes of the sea lamprey Petromyzon marinus L. are able to convert tritiated testosterone into tritiated 15alpha-hydroxytestosterone (15alpha-T)
S M Lowartz et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 138(2), 119-127 (2004-06-15)
Gonads of premetamorphosing larval (PML), transforming (TL) and newly metamorphosed (juvenile) sea lampreys (JL) (Petromyzon marinus) were incubated in vitro with tritiated pregnenolone ([(3)H]P(5)), progesterone ([(3)H]P(4)), and androstenedione ([(3)H]A(4)) to identify the major products of steroidogenesis in early developmental stages.
Bradley A Young et al.
General and comparative endocrinology, 151(1), 108-115 (2007-02-03)
The sea lamprey (Petromyzon marinus) is one of the earliest extant vertebrates for which the hypothalamic-pituitary-gonadal (HPG) axis has been shown to control and regulate reproduction in a similar fashion to gnathostome vertebrates. While the two forms of gonadotropin-releasing hormones

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