GSTM4
glutathione S-transferase mu 4
Synonyms:
GSTM4-4, GTM4
Species:
Human GSTM4 (2948), Mouse Gstm4 (14865), Rat Gstm4 (499689), domestic cat GSTM4 (101100824), dog GSTM4 (479912)
UniProtKB ID:
Gene ID:
- Human(2948) Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]
- Mouse(14865) glutathione S-transferase, mu 4
- Rat(499689) glutathione S-transferase mu 4
- domestic cat(101100824) glutathione S-transferase mu 4
- dog(479912) glutathione S-transferase mu 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-GSTM4 antibody produced in mouse, clone 4B4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-GSTM4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-GSTM4, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Cell Lines
Product Number
Description
Species