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SML3555

Sigma-Aldrich

Pirmenol

≥98% (HPLC)

Synonym(s):

CL-845, cis-(±)-α-[3-(2,6-Dimethyl-1-piperidinyl)propyl]-α-phenyl-2-pyridinemethanol, rel-α-​[3-​[(2R,​6S)​-​2,​6-Ddimethyl-​1-​piperidinyl]​propyl]​-​α-​phenyl-​2-​pyridinemethanol

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About This Item

Empirical Formula (Hill Notation):
C22H30N2O
CAS Number:
Molecular Weight:
338.49
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

, White to v. dark grey

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C1=CC=CC=C1)(C2=NC=CC=C2)CCCN3[C@@H](C)CCC[C@H]3C

InChI

1S/C22H30N2O/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3/t18-,19+,22?

InChI key

APUDBKTWDCXQJA-QIDMFYOTSA-N

Biochem/physiol Actions

Pirmenol is an antiarrhythmic agent class Ia that exhibit long half-life and low toxicities. Pirmenol suppresses premature ventricular contractions in human studies.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart.
Watanabe Y, Hara Y, Tamagawa M, Nakaya H.
European Journal of Pharmacology (1997)
Pirmenol: an antiarrhythmic drug with unique electrocardiographic features--a double-blind placebo-controlled comparison with quinidine
Salerno DM, Fifield J, Farmer C, Hodges M.
Clinical Cardiology (1991)
CL-845 (pirmenol hydrochloride): a new orally effective long-acting antiarrhythmic agent
Steffe TJ, Mertz TE, Hastings SG, Potoczak RE, Kaplan HR.
Journal of Pharmacology and Experimental Therapeutics (1980)

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