P9248

PD 169316

≥98% (HPLC), solid

• Synonym(s): 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
• Empirical Formula (Hill Notation): C₂₀H₁₃FN₄O₂
• CAS Number: 152121-53-4
• Molecular Weight: 360.34
• MDL number: MFCD12405019
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278156
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: faint yellow to dark orange
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• InChI key: BGIYKDUASORTBB-UHFFFAOYSA-N
• Gene Information: human ... MAPK14(1432)

Description

General description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Application

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H301,H315,H318,H335
• Precautionary Statements: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves